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95312
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MOLECULAR ONCOLOGY/IMMUNOLOGY AND ENDOCRINOLOGY
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10
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Module “Molecular Oncology/Immunology”
Molecular Oncology - Cancer represents a special type of pathology that can be potentially dangerous even when affecting only an individual cell. At a molecular (biochemical-interactions) level, fundamental cellular functions (proliferation, apoptosis, differentiation, tissue architecture) are controlled by networks of signaling-proteins. Signaling-proteins networks decide when and in which way a cell will activate the above mentioned basic cellular functions. Special discrete sets of mutations / alterations, inheritable at the somatic level, from a parental to a daughter cell, can give origin to new progressively transformed cells, endowed with more permissive controls of these same functions. We want the student to learn the basic features of this pre-neoplastic and subsequently neoplastic transformation process. By about ten years, medicinal chemistry has started to discover selective inhibitors of altered signaling-proteins affected by excess of function (especially kinase inhibitors). We want the student to enter the world of possible selective corrections of altered pathways and altered signaling-network sub-regions.
Molecular Immunology - This course is aimed to provide a broad view of the current knowledge of the molecular mechanisms involved in the antigen-specific immune response and in innate immunity. Examples of translational applications of this basic knowledge to biotechnology approaches of therapy and diagnosis in neoplastic and immune-mediated diseases will be discussed.
Module “Endocrinology”
Elements of clinical and experimental endocrinology. Analytical methods for the evaluation of serum hormonal levels, principles of diagnosis of endocrinological diseases.
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95313 - MOLECULAR ONCOLOGY/IMMUNOLOGY
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MED/04
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5
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5 CFU CARATTERIZZANTI Discipline Medico-Chirurgiche e Riproduzione Umana
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Molecular Oncology - Cancer represents a special type of pathology that can be potentially dangerous even when affecting only an individual cell. At a molecular (biochemical-interactions) level, fundamental cellular functions (proliferation, apoptosis, differentiation, tissue architecture) are controlled by networks of signaling-proteins. Signaling-proteins networks decide when and in which way a cell will activate the above mentioned basic cellular functions. Special discrete sets of mutations / alterations, inheritable at the somatic level, from a parental to a daughter cell, can give origin to new progressively transformed cells, endowed with more permissive controls of these same functions. We want the student to learn the basic features of this pre-neoplastic and subsequently neoplastic transformation process. By about ten years, medicinal chemistry has started to discover selective inhibitors of altered signaling-proteins affected by excess of function (especially kinase inhibitors). We want the student to enter the world of possible selective corrections of altered pathways and altered signaling-network sub-regions.
Molecular Immunology - This course is aimed to provide a broad view of the current knowledge of the molecular mechanisms involved in the antigen-specific immune response and in innate immunity. Examples of translational applications of this basic knowledge to biotechnology approaches of therapy and diagnosis in neoplastic and immune-mediated diseases will be discussed.
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95314 - ENDOCRINOLOGY
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MED/13
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5
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5 CFU CARATTERIZZANTI Discipline Medico-Chirurgiche e Riproduzione Umana
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Elements of clinical and experimental endocrinology. Analytical methods for the evaluation of serum hormonal levels, principles of diagnosis of endocrinological diseases.
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10 CFU tra i seguenti insegnamenti:
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95323
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COMPUTATIONAL TECHNIQUES OF DRUG DEVELOPMENT AND DRUG SYNTHESIS
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CHIM/08
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5
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5 CFU A SCELTA A Scelta dello Studente
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The course aims to provide key concepts of drug design and synthesis, with particular reference to innovative methodologies.
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95326
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INSTRUMENTATION FOR GENOMICS AND PROTEOMICS AND ADVANCED MICROSCOPY
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5
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Instrumentation in genomics
Overview of the most used technologies applied to genomic analysis both at the chromosomal and at the DNA sequence level.
Instrumentation in proteomics
The course aims to provide the basis for the understanding of the mass spectrometry techniques useful for proteins characterization.
Chromatographic Techniques
The unit provides an overview of the sampling procedures and chromatographic techniques used in proteomics.
Advanced Microscopy
We will cover the scientific theoretical path that moves the distance from the three-dimensional confocal fluorescence microscopy until the very recent developments in the so-called Multiphoton. Will be analyzed by confocal microscopy and its evolution towards a new mode of excitation of the fluorescence, which is of particular interest in the study of three-dimensional perishable samples such as cells and molecular systems.
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95327 - INSTRUMENTATION FOR GENOMICS AND PROTEOMICS
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BIO/10
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3
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3 CFU A SCELTA A Scelta dello Studente
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Instrumentation in genomics
Overview of the most used technologies applied to genomic analysis both at the chromosomal and at the DNA sequence level.
Instrumentation in proteomics
The course aims to provide the basis for the understanding of the mass spectrometry techniques useful for proteins characterization.
Chromatographic Techniques
The unit provides an overview of the sampling procedures and chromatographic techniques used in proteomics.
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95328 - ADVANCED MICROSCOPY
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FIS/07
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2
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2 CFU A SCELTA A Scelta dello Studente
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We will cover the scientific theoretical path that moves the distance from the three-dimensional confocal fluorescence microscopy until the very recent developments in the so-called Multiphoton. Will be analyzed by confocal microscopy and its evolution towards a new mode of excitation of the fluorescence, which is of particular interest in the study of three-dimensional perishable samples such as cells and molecular systems.
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95329
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MOLECULAR BASIS OF DISEASE AND GENE THERAPY
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5
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Molecular Bases of Pathologies
The course is aimed at exploring specific example pathologies as consequences of molecular alterations, with particular focus on tumors, and at illustrating novel methodological strategies to investigate disease pathogenetic mechanisms and identify new therapeutic targets.
Gene Therapy
To allow the student to acquire a detailed knowledge of the current and up-to date gene transfer and therapy approaches, along with their evolution in clinical settings, and to correlate them with the current knowledge on physiology, molecular biology and genetic engineering technologies; to allow the student to envisage possible future applications of gene therapy based on the current knowledge of monogenic diseases with a relevant clinical prevalence.
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95330 - MOLECULAR BASIS OF DISEASE
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MED/04
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2.5
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2.5 CFU A SCELTA A Scelta dello Studente
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The course is aimed at exploring specific example pathologies as consequences of molecular alterations, with particular focus on tumors, and at illustrating novel methodological strategies to investigate disease pathogenetic mechanisms and identify new therapeutic targets.
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95331 - GENE THERAPY
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BIO/13
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2.5
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2.5 CFU A SCELTA A Scelta dello Studente
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To allow the student to acquire a detailed knowledge of the current and up-to date gene transfer and therapy approaches, along with their evolution in clinical settings, and to correlate them with the current knowledge on physiology, molecular biology and genetic engineering technologies; to allow the student to envisage possible future applications of gene therapy based on the current knowledge of monogenic diseases with a relevant clinical prevalence.
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95324
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NEUROBIOLOGY AND NEUROPHYSIOLOGY
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BIO/09
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5
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5 CFU A SCELTA A Scelta dello Studente
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The purpose of the course is to give an overview of molecular mechanisms that regulate functions in the nervous system with special emphasis on cellular and molecular mechanisms that regulate neurotransmission. In particular students receive a detailed information on the generation and propagation of the electrical signal in single neurons up to the complexity of the firing of neurons in network. Mechanisms underlying synaptic plasticity, fundamental for higher function such as learning and memory, will be analyzed in details. Moreover thank to the laboratory-activity, the students will learn basic skills in vitro electrophysiology (extra- and intracellular recordings, patch-clamp) and functional imaging techniques. Different recording modes and their advantages and disadvantages will be dealt with. By the end of the course the students should be able to understand the possibilities and the limitations of the different in vitro experimental approaches in neuroscience research and to design experiments in which the techniques are applied in a relevant manner to deal with up to date neurophysiology questions.
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95335
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NEUROPHARMACOLOGY AND NEUROPATHOLOGY
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5
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Neuropharmacology
The aim of the course is to provide the students with knowledge about the main classes of drugs active on the central nervous system. The course will be focused to study the main pharmacological strategies used to modulate the neurochemical and behavioral responses to affect the pathogenetic mechanisms of the main CNS diseases.
Neuropathology
The aim of the course is to present and discuss the neuropathology of the most common disorders of the central nervous system , such as Parkinson disease and Multiple Sclerosis. Moreover the animal models of multiple sclerosis, experimental allergic encephalomyelitis and of genetic disease of the peripheral nervous system will be presented.
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95336 - NEUROPHARMACOLOGY
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BIO/14
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2.5
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2.5 CFU A SCELTA A Scelta dello Studente
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The aim of the course is to provide the students with knowledge about the main classes of drugs active on the central nervous system. The course will be focused to study the main pharmacological strategies used to modulate the neurochemical and behavioral responses to affect the pathogenetic mechanisms of the main CNS diseases.
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95337 - NEUROPATHOLOGY
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MED/26
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2.5
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2.5 CFU A SCELTA A Scelta dello Studente
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The aim of the course is to present and discuss the neuropathology of the most common disorders of the central nervous system , such as Parkinson disease and Multiple Sclerosis. Moreover the animal models of multiple sclerosis, experimental allergic encephalomyelitis and of genetic disease of the peripheral nervous system will be presented.
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95332
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PHARMACOGENOMICS, PHARMACOGENETICS AND DRUG METABOLISM
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5
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The aim of this course is to provide the students with knowledge about fundamental concepts of Pharmacogenomics and Pharmacogenetics. The course will be focused to study the changes of cellular and molecular mechanisms which regulate the different pharmacological responses. Moreover, the course will underline the most interesting progresses in therapy due to this new potential pharmacological approach and the possible future therapeutic development.
The course also provides the students with the basic concepts of the metabolism of drugs and other xenobiotics. Besides describing the main Phase 1 and 2 reactions involved, the course deal with the latest in vivo and in vitro technologies used to study drug metabolism, as well as the main enzymatic systems responsible for these biotransformations.
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95333 - PHARMACOGENOMICS AND PHARMACOGENETICS
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BIO/14
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2.5
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2.5 CFU A SCELTA A Scelta dello Studente
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The aim of this course is to provide the students with knowledge about fundamental concepts of Pharmacogenomics and Pharmacogenetics. The course will be focused to study the changes of cellular and molecular mechanisms which regulate the different pharmacological responses. Moreover, the course will underline the most interesting progresses in therapy due to this new potential pharmacological approach and the possible future therapeutic development.
The course also provides the students with the basic concepts of the metabolism of drugs and other xenobiotics.
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95334 - DRUG METABOLISM
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CHIM/09
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2.5
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2.5 CFU A SCELTA A Scelta dello Studente
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The course deal with the latest in vivo and in vitro technologies used to study drug metabolism, as well as the main enzymatic systems responsible for these biotransformations.
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95322
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PROTEIN ENGINEERING
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BIO/10
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5
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5 CFU A SCELTA A Scelta dello Studente
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The aim of the course is to provide students with theoretical knowledge but also practical on the assumptions and techniques underlying the engineering of proteins and antibodies. In addition, part of the course will be dedicated to the deepening of the techniques of chemical synthesis of proteins.
Regarding the form of Protein engineering, will initially be resumed and expanded some concettivi base relative to the production of recombinant proteins. Thus, different approaches will be analyzed in order to obtain modified proteins or optimized for different applications, the techniques used and the systems of selection / screening, and using examples from the literature or used for production / commercial.
In the section of the course on the engineering of antibodies will be given with the three-dimensional structure of immunoglobulins and will be addressed later, in the chronological order of creation, the different techniques of humanization and production of recombinant phage display antibody.
In the form of Chemical Engineering explain the main techniques for the chemical synthesis of peptides and proteins and applications resulting from these techniques.
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95325
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REGENERATIVE MEDICINE AND TISSUE ENGINEERING
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BIO/13
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5
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5 CFU A SCELTA A Scelta dello Studente
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This class will offer a comprehensive view on the current state-of-the-art of regenerative medicine and tissue engineering to the undergraduate students, asking them to examine in depth specific topics in order to develop higher criticism skills.
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