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PROGRAMMAZIONE DIDATTICA COORTE A.A. 2025/2026
CORSO DI LAUREA MAGISTRALE in 11922 MEDICAL-PHARMACEUTICAL BIOTECHNOLOGY (classe LM-9 R )

SCHEDA INFORMATIVA

Sede amministrativa:  GE
Classe delle lauree in: 

Biotecnologie mediche, veterinarie e farmaceutiche (classe LM-9 R)

Durata:  2 anni
Indirizzo web:  http://www.biotecnologie.unige.it
Dipartimento di riferimento:  DIPARTIMENTO DI MEDICINA SPERIMENTALE

PIANO DI STUDI

1° anno (coorte 2025/2026)

Codice Disciplina Settore CFU Tipologia/Ambito Obiettivi Formativi Propedeuticità
98800 STRUCTURAL BIOLOGY AND NANOTECHNOLOGY (WITH LABORATORY) BIO/10 6 6 CFU CARATTERIZZANTI Discipline biotecnologiche comuni
The course consist of two modules: Structural Biology and Nanotechnology. The Structural Biology module aims to provide the basis for understanding the three-dimensional structure of macromolecules of biochemical and biotechnological interest such as proteins and nucleic acids. The functional aspects to structural ones will be discussed through various examples present in the literature. The Nanotechnology module aims to provide students with an overview of the latest and most advanced nanobiotechnologies and nanobiomaterials. In particular, the two aspects of nanobioscience and nanobiotechnology application take place: structural proteomics and functional proteomics. In the first case, the novel method of protein nanocrystallography and the advanced synchrotron radiation techniques, including micro and nano-focussed high intense synchrotron radiation and the new trends in radiation damage reduction are presented. In the second case, the most innovative technologies of protein microarrays NAPPA (Nucleic Acid Programmable protein Array) and their fluorescent-label as well as label-free technology of are demonstrated. In the both cases the application to the regenerative medicine are underlined.

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95305 HUMAN GENETICS AND MOLECULAR PATHOLOGY AND LABORATORY 10 In-depth knowledge about inheritance as it occurs in human beings, and comprehension of the main molecular and cellular mechanisms related to the pathogenesis of inherited and acquired diseases.

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  95306 - HUMAN GENETICS AND LABORATORY MED/03 5 5 CFU CARATTERIZZANTI Medicina di laboratorio e diagnostica
Knowledge of the mode of inheritance of genetic disorders in humans and the underlying molecular mechanisms. Comprehension of experimental approaches for the detection of genetic factors associated to human diseases. Basic concepts on population genetics.

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  95308 - MOLECULAR PATHOLOGY AND LABORATORY MED/04 5 5 CFU CARATTERIZZANTI Discipline biotecnologiche comuni
In-depth knowledge about inheritance as it occurs in human beings, and comprehension of the main molecular and cellular mechanisms related to the pathogenesis of inherited and acquired diseases.

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95309 PHARMACOLOGY AND TOXICOLOGY AND LABORATORY 10 Module “Pharmacology” The aim of this course is to provide the students with knowledge about fundamental concepts of the main pharmacological classes, the basic concepts of pharmacokinetics and pharmacodynamics, correlated to the study and the development of new drugs, and the methodologies of pharmacological experimentation. The course will be focused to study cellular molecular mechanisms of the action of drugs, deepening their receptorial mechanisms and signal transduction. Moreover, the course will underline the progresses, obtained using new technologies, molecular biology and biotechnology, towards the investigation of innovative pharmaceuticals molecules and the finding of new therapeutic targets. Module “Toxicology” The Toxicology module aims at providing students with the basic knowledge regarding the interactions between xenobiotics and living organisms and the mechanisms through which such interactions can lead to harmful effects.

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  95310 - PHARMACOLOGY AND LABORATORY BIO/14 5 5 CFU CARATTERIZZANTI Discipline farmaceutiche
The aim of this course is to provide the students with knowledge about fundamental concepts of the main pharmacological classes, the basic concepts of pharmacokinetics and pharmacodynamics, correlated to the study and the development of new drugs, and the methodologies of pharmacological experimentation. The course will be focused to study cellular molecular mechanisms of the action of drugs, deepening their receptorial mechanisms and signal transduction. Moreover, the course will underline the progresses, obtained using new technologies, molecular biology and biotechnology, towards the investigation of innovative pharmaceuticals molecules and the finding of new therapeutic targets.

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  95311 - TOXICOLOGY AND LABORATORY BIO/14 5 5 CFU CARATTERIZZANTI Discipline medico-chirurgiche e della riproduzione umana
The Toxicology module aims at providing students with the basic knowledge regarding the interactions between xenobiotics and living organisms and the mechanisms through which such interactions can lead to harmful effects.

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95315 PHYSICAL CHEMISTRY CHIM/02 6 6 CFU CARATTERIZZANTI Discipline fondamentali applicate alle biotecnologie
Acquire methodological rigor and mathematical formalism to interpret and describe the fundamental phenomena that underlie the chemical-physical systems. Particular attention will be paid to the description and understanding of the energy profile of chemical systems as well as to the physical-chemical phenomena as a function of time.

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98802 ADVANCED MOLECULAR BIOLOGY (WITH LABORATORY) BIO/11 6 6 CFU CARATTERIZZANTI Discipline biotecnologiche comuni
The objective of the course is to deepen the molecular biology basic knowledge tackling in detail the functional mechanisms of nuclear biomolecular processes. Furthermore, students will develop methodological instruments to be able to face molecular biology challenges in applied research.

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98799 HUMAN BIOCHEMISTRY (WITH LABORATORY) BIO/10 10 10 CFU CARATTERIZZANTI Discipline biotecnologiche comuni
The course is structured in two modules: Organ Biochemistry and Diagnostic Biotechnology. The Biochemistry module aims to analyze in details some aspects of protein biochemistry and tissue/ specialized organ biochemistry. During the laboratory, selected innovative biochemical methods and technologies will be discussed, using examples from the literature. The module of Diagnostic Biotechnology, aims to introduce students to the methods derived from basic biotechnologies that were transferred to medical diagnostics; know the main analyses of clinical biochemistry and their interpretation to verify metabolism and function of different organs.

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98801 CREATION, ORGANIZATION AND MANAGEMENT OF COMPANY SECS-P/07 5 5 CFU CARATTERIZZANTI Scienze umane, economiche, giuridiche e politiche pubbliche
The creation of a consciousness and an economic knowledge in the students enough to include them in the organizational context of any company. The knowledge of the concepts of budgeting and reporting, governance and business management so as to make the student aware of an operator in any context added.

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95321 INTERNSHIPS 8 8 CFU ALTRE ATTIVITA' Tirocini formativi e di orientamento
Internship Lab or Stage Company.

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2° anno (coorte 2025/2026)

Codice Disciplina Settore CFU Tipologia/Ambito Obiettivi Formativi Propedeuticità
98798 STEM CELL BIOLOGY AND REGENERATIVE MEDICINE (WITH LABORATORY) BIO/13 6 6 CFU CARATTERIZZANTI Discipline biotecnologiche comuni
Analysis of stem cell biology, focusing on their differentiation and therapeutic potential (including somatic nuclear transfer and cloning).

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98804 MOLECULAR ONCOLOGY, IMMUNOLOGY, AND ENDOCRINOLOGY 10

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  98805 - MOLECULAR ONCOLOGY, IMMUNOLOGY MED/04 5 5 CFU CARATTERIZZANTI Discipline medico-chirurgiche e della riproduzione umana
Molecular Oncology Cancer represents a special type of pathology that can be potentially dangerous even when affecting only an individual cell. At a molecular (biochemical-interactions) level, fundamental cellular functions (proliferation, apoptosis, differentiation, tissue architecture) are controlled by networks of signaling-proteins. Signaling-proteins networks decide when and in which way a cell will activate the above mentioned basic cellular functions. Special discrete sets of mutations / alterations, inheritable at the somatic level, from a parental to a daughter cell, can give origin to new progressively transformed cells, endowed with more permissive controls of these same functions. We want the student to learn the basic features of this pre-neoplastic and subsequently neoplastic transformation process. By about ten years, medicinal chemistry has started to discover selective inhibitors of altered signaling-proteins affected by excess of function (especially kinase inhibitors). We want the student to enter the world of possible selective corrections of altered pathways and altered signaling-network sub-regions. Molecular Immunology This course is aimed to provide a broad view of the current knowledge of the molecular mechanisms involved in the antigen-specific immune response and in innate immunity. Examples of translational applications of this basic knowledge to biotechnology approaches of therapy and diagnosis in neoplastic and immune-mediated diseases will be discussed.

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  98806 - ENDOCRINOLOGY MED/13 5 5 CFU CARATTERIZZANTI Discipline medico-chirurgiche e della riproduzione umana
Elements of clinical and experimental endocrinology. Analytical methods for the evaluation of serum hormonal levels, principles of diagnosis of endocrinological diseases.

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98803 DEVELOPMENTAL NEUROBIOLOGY (WITH LABORATORY) BIO/06 6 6 CFU AFFINI O INTEGRATIVE Attività formative affini o integrative
This course will equip students with a comprehensive understanding of the morphogenetic, cellular, and molecular mechanisms that drive nervous system development in various invertebrate and vertebrate animals and in humans.

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118083 ANIMAL MODELS FOR BIOTECHNOLOGY 6 The aim of the course is to provide students with the essential informations necessaries to carry out experiments on laboratory animals. Particularly, wide information on different animal models and their usefulness are given. Additionally, all necessary indications on law dispositions about animal research and on animal welfare are specified. Furthermore, the students will learn all methodologies currently in use to create mutant animals, including new scientific approaches. Specific examples are illustrated.

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  118084 - ANATOMY OF ANIMAL MODELS: FUNCTION AND EVOLUTIONARY ASPECTS BIO/06 2 2 CFU AFFINI O INTEGRATIVE Attività formative affini o integrative

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  118085 - BEHAVIOURAL PHYSIOLOGY OF EXPERIMENTAL ANIMAL MODELS FOR BIOMEDICAL RESEARCH BIO/09 2 2 CFU AFFINI O INTEGRATIVE Attività formative affini o integrative

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  118086 - MOLECULAR AND CELLULAR ENGINEERING OF EXPERIMENTAL ANIMAL MODELS FOR TRANSATIONAL RESEARCH BIO/13 2 2 CFU AFFINI O INTEGRATIVE Attività formative affini o integrative

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10 CFU tra i seguenti insegnamenti:
98807 CELL BIOLOGY APPLIED TO BIOMEDICINE BIO/13 5 5 CFU A SCELTA A scelta dello studente
This class will offer a comprehensive view on the current state-of-the-art of regenerative medicine and tissue engineering to the undergraduate students, asking them to examine in depth specific topics in order to develop higher criticism skills.

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102000 CLINICAL EMBRYOLOGY BIO/06 2.5 2.5 CFU A SCELTA A scelta dello studente
The advanced course aims to deepen the theoretical and practical aspects of clinical embryology discussing IVF laboratory safety and quality issues, discussing the current practices in IVF and developments in embryology and IVF technology.

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95323 COMPUTATIONAL TECHNIQUES OF DRUG DEVELOPMENT AND DRUG SYNTHESIS CHIM/08 5 5 CFU A SCELTA A scelta dello studente
The course aims to provide key concepts of drug design and synthesis, with particular reference to innovative methodologies.

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98817 DRUG METABOLISM CHIM/09 2.5 2.5 CFU A SCELTA A scelta dello studente
The course provides the students with the basic concepts of the metabolism of drugs and other xenobiotics. Besides describing the main Phase 1 and 2 reactions involved, the course deal with the latest in vivo and in vitro technologies used to study drug metabolism, as well as the main enzymatic systems responsible for these biotransformations.

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98815 GENE THERAPY BIO/13 2.5 2.5 CFU A SCELTA A scelta dello studente
To allow the student to acquire a detailed knowledge of the current and up-to date gene transfer and therapy approaches, along with their evolution in clinical settings, and to correlate them with the current knowledge on physiology, molecular biology and genetic engineering technologies; to allow the student to envisage possible future applications of gene therapy based on the current knowledge of monogenic diseases with a relevant clinical prevalence.

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111527 INSTRUMENTATION FOR PROTEOMICS BIO/12 2.5 2.5 CFU A SCELTA A scelta dello studente
From biochemistry to proteomics The course aims to provide the basis for understanding the main techniques applied for the study of proteins, including: one-dimensional polyacrylamide gel electrophoresis in native or denatured and denatured reduced and alkylated conditions, zymograms, different types of two-dimensional electrophoresis (i.e. titration curves, blue native electrophoresis, and high-resolution two-dimensional gel electrophoresis), western blots, different methods of proteins detection gels (coomassie, colloidal, silver nitrate and fluorescence staining), main chromatography techniques including methods that use magnetic nano beads, particularly suitable for robotic automation systems, mass spectrometry high resolution, direct and indirect ELISA, membrane and microscope slide protein arrays. Protein samples preparation The course aims to provide an overview of the main biochemical-physical methods to address and solve most of the problems in the preparation of protein samples such as most common biological fluids (serum, plasma, liquor and urine), cells, extracellular vesicles and tissues for the methods indicated above. Bioinformatics analysis Finally, the course aims to provide the basis for the analysis of big data obtained from protein microarray and/or mass spectrometry experiments. In particular, attention will be paid to: a) how to normalize data, b) the use of the most recent classification, prediction, and correlation algorithms between experimental features and biochemical-clinical data of samples such as weighted gene co-expression network analysis, machine learning and supervised /unsupervised cluster analysis, c) which statistical tests to use, d) how to choose the variables of interest, e) and the gene ontology enrichment analysis for the identification of biological processes and metabolic pathways perturbed in a case-control experiment.

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98814 MOLECULAR BASES OF THERAPY DESIGN MED/04 2.5 2.5 CFU A SCELTA A scelta dello studente
The course is aimed at exploring specific example pathologies as consequences of molecular alterations, with particular focus on tumors, and at illustrating novel methodological strategies to investigate disease pathogenetic mechanisms and identify new therapeutic targets.

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95324 NEUROBIOLOGY AND NEUROPHYSIOLOGY BIO/09 5 5 CFU A SCELTA A scelta dello studente
The purpose of the course is to give an overview of molecular mechanisms that regulate functions in the nervous system with special emphasis on cellular and molecular mechanisms that regulate neurotransmission. In particular students receive a detailed information on the generation and propagation of the electrical signal in single neurons up to the complexity of the firing of neurons in network. Mechanisms underlying synaptic plasticity, fundamental for higher function such as learning and memory, will be analyzed in details. Moreover thank to the laboratory-activity, the students will learn basic skills in vitro electrophysiology (extra- and intracellular recordings, patch-clamp) and functional imaging techniques. Different recording modes and their advantages and disadvantages will be dealt with. By the end of the course the students should be able to understand the possibilities and the limitations of the different in vitro experimental approaches in neuroscience research and to design experiments in which the techniques are applied in a relevant manner to deal with up to date neurophysiology questions.

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98820 NEUROIMMUNOPATHOLOGY MED/26 2.5 2.5 CFU A SCELTA A scelta dello studente
The aim of the course is to present and discuss the neuropathology of the most common disorders of the central nervous system , such as Parkinson disease and Multiple Sclerosis. Moreover the animal models of multiple sclerosis, experimental allergic encephalomyelitis and of genetic disease of the peripheral nervous system will be presented.

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98818 NEUROPHARMACOLOGY BIO/14 2.5 2.5 CFU A SCELTA A scelta dello studente
The aim of the course is to provide the students with knowledge about the main classes of drugs active on the central nervous system. The course will be focused to study the main pharmacological strategies used to modulate the neurochemical and behavioral responses to affect the pathogenetic mechanisms of the main CNS diseases.

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98816 PHARMACOGENOMICS AND PHARMACOGENETICS BIO/14 2.5 2.5 CFU A SCELTA A scelta dello studente
The aim of this course is to provide the students with knowledge about fundamental concepts of Pharmacogenomics and Pharmacogenetics. The course will be focused to study the changes of cellular and molecular mechanisms which regulate the different pharmacological responses. Moreover, the course will underline the most interesting progresses in therapy due to this new potential pharmacological approach and the possible future therapeutic development.

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95322 PROTEIN EXPRESSION AND ENGINEERING BIO/10 5 5 CFU A SCELTA A scelta dello studente
The aim of the course is to provide students with theoretical knowledge but also practical on the assumptions and techniques underlying the engineering of proteins and antibodies. In addition, part of the course will be dedicated to the deepening of the techniques of chemical synthesis of proteins. Regarding the form of Protein engineering, will initially be resumed and expanded some concettivi base relative to the production of recombinant proteins. Thus, different approaches will be analyzed in order to obtain modified proteins or optimized for different applications, the techniques used and the systems of selection / screening, and using examples from the literature or used for production / commercial. In the section of the course on the engineering of antibodies will be given with the three-dimensional structure of immunoglobulins and will be addressed later, in the chronological order of creation, the different techniques of humanization and production of recombinant phage display antibody. In the form of Chemical Engineering explain the main techniques for the chemical synthesis of peptides and proteins and applications resulting from these techniques.

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95319 FINAL EXAM 20 20 CFU PROVA FINALE Per la prova finale
The final exam consists in the presentation and discussion of a thesis written Experimental individual in which the candidate will highlight the research work, carried out at the laboratories of Professors and / or companies in the sector, on a specific theme.

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95320 OTHER TRAINING ACTIVITIES 1 1 CFU ALTRE ATTIVITA' Altre conoscenze utili per l'inserimento nel mondo del lavoro
Further knowledge on specific issues.

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